Garfunkel and Oates is a two girl singing group. Think of them as the female Tenacious D or Flight of the Concords. They would probably hate such an oversimplified description, but the shoe definitely fits. Their songs blend, intellect, humor, pop culture, and the daily ridiculousness of life.
In this song they sing about how easy it is to acquire a medical marijuana card in California. It's funny because it's true, and because not many people talk about it outside of their personal social groups.